Synthesized peptide derived from human LAB (Phospho-Tyr136)

This antibody detects endogenous levels of LAB (Phospho-Tyr136) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NSyEN

LAT2 LAB NTAL WBS15 WBSCR15 WBSCR5 HSPC046

Linker for activation of T-cells family member 2

Linker for activation of T-cells family member 2 ;
Linker for activation of B-cells ;
Membrane-associated adapter molecule ;
Non-T-cell activation linker ;
Williams-Beuren syndrome chromosomal region 15 protein ;
Williams-Beuren syndrome chromosomal region 5 protein ;

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008],

Disease:Defects in LAT2 may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.,PTM:May be polyubiquitinated.,PTM:Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.,subcellular location:Present in lipid rafts.,subunit:When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.,tissue specificity:Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).,

Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.