Synthesized phosho peptide around human Stat5 (Tyr694)

This antibody detects endogenous levels of Human Mouse Stat5 (phospho-Tyr694)

STAT5B

Signal transducer and activator of transcription 5B (Tyr694)

Signal transducer and activator of transcription 5B

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors , STAT family members are phosphorylated by the receptor associated kinases , and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands , such as IL2 , IL4 , CSF1 , and different growth hormones. It has been shown to be involved in diverse biological processes , such as TCR signaling , apoptosis , adult mammary gland development , and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi

Disease:Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone , and resistance to hexogeneous hormone therapy. ,Function:Carries out a dual Function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription. ,online information:STAT5 entry ,online information:STAT5B mutation db ,PTM:Tyrosine phosphorylated. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus in response to phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity) . Interacts with NCOA1 , NMI and SOCS7. ,

Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .

>>ErbB signaling pathway ;
>>Chemokine signaling pathway ;
>>Necroptosis ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Prolactin signaling pathway ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Growth hormone synthesis , secretion and action ;
>>Hepatitis B ;
>>Measles ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Chemical carcinogenesis - receptor activation ;
>>Chronic myeloid leukemia ;
>>Acute myeloid leukemia ;
>>Non-small cell lung cancer