MLKL Phospho ser345 Rabbit pAb
-YP1710
主要信息
Target
MLKL Phospho Ser345
Host Species
Rabbit
Reactivity
Human
Applications
WB
MW
52kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1710
规格
价格
货期
数量
200μL
￥4,680.00
一个月
0
100μL
￥2,800.00
一个月
0
50μL
￥1,500.00
一个月
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
52kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human MLKL Phospho-ser345
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特异性:
This antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
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基因名称:
MLKL
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蛋白名称:
MLKL Phospho-ser345
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别名:
Mixed lineage kinase domain-like protein
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背景:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
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功能:
Domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
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细胞定位:
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
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组织表达:
研究领域:
>>Necroptosis ;
>>TNF signaling pathway ;
>>Salmonella infection
>>TNF signaling pathway ;
>>Salmonella infection
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信号通路
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货号: YP1710
规格
价格
货期
数量
200μL
￥4,680.00
一个月
0
100μL
￥2,800.00
一个月
0
50μL
￥1,500.00
一个月
0
加入购物车
已收藏
收藏
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