GRK 2 (Phospho Ser685) Rabbit pAb
-YP1225
主要信息
Target
GRK 2 Phospho Ser685
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
80kD (Observed)
Conjugate/Modification
Phospho
货号: YP1225
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:10000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This detects endogenous levels of GRK2 (Phospho-Ser685).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGsAN
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
80kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phospho derived from human GRK2 (Phospho-Ser685)
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特异性:
This detects endogenous levels of GRK2 (Phospho-Ser685).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGsAN
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基因名称:
ADRBK1 BARK BARK1 GRK2
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蛋白名称:
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled receptor kinase 2)
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别名:
ADRBK1 ;
BARK ;
BARK1 ;
GRK2 ;
Beta-adrenergic receptor kinase 1 ;
Beta-ARK-1 ;
G-protein coupled receptor kinase 2
BARK ;
BARK1 ;
GRK2 ;
Beta-adrenergic receptor kinase 1 ;
Beta-ARK-1 ;
G-protein coupled receptor kinase 2
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背景:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate. ,Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors , probably inducing a desensitization of them. ,online information:Beta adrenergic receptor kinase entry ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 RGS domain. ,subunit:Interacts with GIT1 (By similarity) . Interacts with , and phosphorylates chemokine-stimulated CCR5. ,tissue specificity:Expressed in peripheral blood leukocytes. ,
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细胞定位:
Cytoplasm . Cell membrane . Cell junction , synapse , postsynapse . Cell junction , synapse , presynapse .
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组织表达:
研究领域:
>>Chemokine signaling pathway ;
>>Endocytosis ;
>>Hedgehog signaling pathway ;
>>Glutamatergic synapse ;
>>Olfactory transduction ;
>>Morphine addiction
>>Endocytosis ;
>>Hedgehog signaling pathway ;
>>Glutamatergic synapse ;
>>Olfactory transduction ;
>>Morphine addiction
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信号通路
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货号: YP1225
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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