Synthesized phospho-peptide around the phosphorylation site of human STAT4 (phospho Tyr693)

Phospho-STAT4 (Y693) Polyclonal Antibody detects endogenous levels of STAT4 protein only when phosphorylated at Y693.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KGyVP

STAT4

Signal transducer and activator of transcription 4

STAT4 ;
Signal transducer and activator of transcription 4

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors , STAT family members are phosphorylated by the receptor associated kinases , and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes , and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq , Aug 2011] ,

Disease:Genetic variations in STAT4 are associated with susceptibility to rheumatoid arthritis (RA) [MIM:180300]. Rheumatoid arthritis is a complex , multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction. ,Disease:Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory , and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin , joints , kidneys , and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. ,Function:Carries out a dual Function: signal transduction and activation of transcription. Involved in IL12 signaling. ,PTM:Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus in response to phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity) . The SH2 domain interacts , in vitro , with IL12RB2 via a short cytoplasmic domain. ,

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

>>Necroptosis ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Inflammatory bowel disease