Neuro D (Phospho Ser274) Rabbit pAb
-YP0473
主要信息
Target
Neuro D Phospho Ser274
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
36kD (Observed)
Conjugate/Modification
Phospho
货号: YP0473
规格
价格
货期
数量
200μL
￥4,680.00
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0
100μL
￥2,800.00
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0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Neuro D (S274) Polyclonal Antibody detects endogenous levels of Neuro D protein only when phosphorylated at S274.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PLsPP
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
36kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Neuro D around the phosphorylation site of Ser274. AA range:240-289
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特异性:
Phospho-Neuro D (S274) Polyclonal Antibody detects endogenous levels of Neuro D protein only when phosphorylated at S274.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PLsPP
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基因名称:
NEUROD1
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蛋白名称:
Neurogenic differentiation factor 1
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别名:
NEUROD1 ;
BHLHA3 ;
NEUROD ;
Neurogenic differentiation factor 1 ;
NeuroD ;
NeuroD1 ;
Class A basic helix-loop-helix protein 3 ;
bHLHa3
BHLHA3 ;
NEUROD ;
Neurogenic differentiation factor 1 ;
NeuroD ;
NeuroD1 ;
Class A basic helix-loop-helix protein 3 ;
bHLHa3
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背景:
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene , and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq , Jul 2008] ,
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功能:
Disease:Defects in NEUROD1 are the cause of maturity onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY [MIM:606391] is characterized by an autosomal dominant mode of inheritance , onset during young adulthood and a primary defect in insulin secretion. ,Function:Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box. ,PTM:Phosphorylated. In islet cells , phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons , phosphorylated on Ser-335; which promotes dendritic growth. ,similarity:Contains 1 basic helix-loop-helix (bHLH) domain. ,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with TCF3/E47. Interacts with RREB1. ,
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细胞定位:
Cytoplasm . Nucleus . In pancreatic islet cells , shuttles to the nucleus in response to glucose stimulation (By similarity) . Colocalizes with NR0B2 in the nucleus. .
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组织表达:
研究领域:
>>Maturity onset diabetes of the young
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货号: YP0473
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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