The antiserum was produced against synthesized peptide derived from human KIF11/Eg5 around the phosphorylation site of Thr926. AA range:892-941

Phospho-Eg5 (T926) Polyclonal Antibody detects endogenous levels of Eg5 protein only when phosphorylated at T926.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GTtPQ

KIF11

Kinesin-like protein KIF11

KIF11 ;
EG5 ;
KNSL1 ;
TRIP5 ;
Kinesin-like protein KIF11 ;
Kinesin-like protein 1 ;
Kinesin-like spindle protein HKSP ;
Kinesin-related motor protein Eg5 ;
Thyroid receptor-interacting protein 5 ;
TR-interacting protein 5 ;
TRIP-5

kinesin family member 11 (KIF11) Homo sapiens This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning , centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq , Jul 2008] ,

Function:Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays. ,PTM:Phosphorylated exclusively on serine during S phase , but on both serine and Thr-926 during mitosis , so controlling the association of KIF11 with the spindle apparatus (probably during early prophase) . Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the kinesin-like protein family. BimC subfamily. ,similarity:Contains 1 kinesin-motor domain. ,subunit:Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex , at least composed of MYSM1 , PCAF , RBM10 and KIF11/TRIP5. ,

Cytoplasm . Cytoplasm , cytoskeleton , spindle pole .