The specific immunogen used to produce this antibody is proprietary information.

Endogenous

MMP9 CLG4B

MMP9 (Cleaved-Met94)

Matrix metalloproteinase-9 ;
MMP-9 ;
92 kDa gelatinase ;
92 kDa type IV collagenase ;
Gelatinase B ;
GELB ;
[Cleaved into: 67 kDa matrix metalloproteinase-9 ;
82 kDa matrix metalloproteinase-9]

catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V. ,cofactor:Binds 2 zinc ions per subunit. ,cofactor:Binds 3 calcium ions per subunit. ,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain. ,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion , thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. ,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5) . ,function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. ,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester. ,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status. ,PTM:N- and O-glycosylated. ,PTM:Processing of the precursor yields different active forms of 64 , 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. ,similarity:Belongs to the peptidase M10A family. ,similarity:Contains 3 fibronectin type-II domains. ,similarity:Contains 4 hemopexin-like domains. ,subunit:Exists as monomer , disulfide-linked homodimer , and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. ,tissue specificity:Produced by normal alveolar macrophages and granulocytes. ,

skeletal system development , immune system development , leukocyte differentiation , myeloid leukocyte differentiation , proteolysis , regulation of cell death , positive regulation of cell death , hemopoiesis , myeloid cell differentiation , extracellular matrix organization , macrophage differentiation , regulation of cell migration , positive regulation of cell migration , collagen catabolic process , collagen metabolic process , regulation of locomotion , positive regulation of locomotion , regulation of apoptosis , extracellular structure organization , positive regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death , multicellular organismal metabolic process , multicellular organismal catabolic process , multicellular organismal macromolecule metabolic process ,hemopoietic or lymphoid organ development , regulation of cell motion , positive regulation of cell motion , regulation of keratinocyte migration , positive regulation of keratinocyte migration ,

Membranous

>>Endocrine resistance ;
>>IL-17 signaling pathway ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>Estrogen signaling pathway ;
>>Relaxin signaling pathway ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Prostate cancer ;
>>Bladder cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis