The antiserum was produced against synthesized peptide derived from the C-terminal region of human ITGA2. AA range:1081-1130

Integrin α2 Polyclonal Antibody detects endogenous levels of Integrin α2 protein.

ITGA2

Integrin alpha-2

ITGA2 ;
CD49B ;
Integrin alpha-2 ;
CD49 antigen-like family member B ;
Collagen receptor ;
Platelet membrane glycoprotein Ia ;
GPIa ;
VLA-2 subunit alpha ;
CD49b

integrin subunit alpha 2(ITGA2) Homo sapiens This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.,polymorphism:Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.,

Membrane; Single-pass type I membrane protein.

Endothelial cell,Liver,Platelet,

>>Phagosome ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Platelet activation ;
>>Hematopoietic cell lineage ;
>>Regulation of actin cytoskeleton ;
>>Human papillomavirus infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Small cell lung cancer ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy