Synthesized peptide derived from human Myeloperoxidase(MPO) AA range: 350-450

This antibody detects endogenous levels of MPO protein.

MPO

Myeloperoxidase

84 kDa myeloperoxidase antibody ;
89 kDa myeloperoxidase antibody ;
EC1.11.2.2 antibody ;
fj80f04 antibody ;
MPO antibody ;
mpx antibody ;
myeloid-specific peroxidase antibody ;
Myeloperoxidase antibody ;
Myeloperoxidase heavy chain antibody ;
Myeloperoxidase light chain antibody ;
PERM_HUMAN antibody ;
wu:fj80f04 antibody

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).

Cytoplasmic

Leukemia,Leukocyte,Liver,Plasma,Saliva

>>Drug metabolism - other enzymes ;
>>Phagosome ;
>>Neutrophil extracellular trap formation ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia