The antiserum was produced against synthesized peptide derived from human LAMB2. AA range:61-110

Laminin β-2 Polyclonal Antibody detects endogenous levels of Laminin β-2 protein.

LAMB2

Laminin subunit beta-2

LAMB2 ;
LAMS ;
Laminin subunit beta-2 ;
Laminin B1s chain ;
Laminin-11 subunit beta ;
Laminin-14 subunit beta ;
Laminin-15 subunit beta ;
Laminin-3 subunit beta ;
Laminin-4 subunit beta ;
Laminin-7 subunit beta ;
Laminin-9 subunit beta ;
S-laminin sub

Laminins , a family of extracellular matrix glycoproteins , are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion , differentiation , migration , signaling , neurite outgrowth and metastasis. Laminins , composed of 3 non identical chains: laminin alpha , beta and gamma (formerly A , B1 , and B2 , respectively) , form a cruciform structure consisting of 3 short arms , each formed by a different chain , and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha , beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery , i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func

Disease:Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities. ,Disease:Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset , diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. ,Domain:Domains VI and IV are globular. ,Domain:The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. ,Function:Binding to cells via a high affinity receptor , laminin is thought to mediate the attachment , migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. ,similarity:Contains 1 laminin IV type B domain. ,similarity:Contains 1 laminin N-terminal domain. ,similarity:Contains 13 laminin EGF-like domains. ,subcellular location:S-laminin is concentrated in the synaptic cleft of the neuromuscular junction. ,subunit:Laminin is a complex glycoprotein , consisting of three different polypeptide chains (alpha , beta , gamma) , which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin) , laminin-4 (S-merosin) , and laminin-7 (KS-laminin) . ,

Secreted , extracellular space , extracellular matrix , basement membrane. S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.

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