Synthesized peptide derived from human protein . at AA range: 1420-1500

LRP6 Polyclonal Antibody detects endogenous levels of protein.

LRP6

Low-density lipoprotein receptor-related protein 6 (LRP-6)

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or , with Frizzled , a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation , proliferation , and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq , Dec 2009] ,

Disease:Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947]. ,Domain:The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1. ,Function:Essential for the Wnt/beta catenin signaling pathway , probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2 , but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis. ,similarity:Belongs to the LDLR family. ,similarity:Contains 20 LDL-receptor class B repeats. ,similarity:Contains 3 LDL-receptor class A domains. ,similarity:Contains 4 EGF-like domains. ,subunit:Interacts with RSPO1 and RSPO3 (By similarity) . Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3. ,tissue specificity:Widely co-expressed with LRP5 during embryogenesis and in adult tissues. ,

Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling , undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling , phosphorylated , aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity) . .

>>mTOR signaling pathway ;
>>Wnt signaling pathway ;
>>Parathyroid hormone synthesis , secretion and action ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathways in cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer