PKD2 (PT1685R) PT™ Rabbit mAb
-YM9527
主要信息
Target
PKD2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
97kD (Calculated)
115kD (Observed)
Conjugate/Modification
Unmodified
货号: YM9527
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
97kD
实测条带
115kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT1685R
同种型
IgG,Kappa
相关产品
Primary Antibodies
PKD2 Rabbit pAb
YT3773
预览→
Primary Antibodies
PKD2 (Phospho Ser876) Rabbit pAb
YP0341
预览→
ELISA Kits
Total PKD2 Cell-Based Colorimetric ELISA Kit
KA4244C
预览→
ELISA Kits
PKD2 (Phospho Ser876) Cell-Based Colorimetric ELISA Kit
KA1415C
预览→
抗原&靶点信息
特异性:
Endogenous
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基因名称:
PRKD2
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蛋白名称:
Serine/threonine-protein kinase D2
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别名:
PRKD2 ;
PKD2 ;
HSPC187 ;
Serine/threonine-protein kinase D2 ;
nPKC-D2
PKD2 ;
HSPC187 ;
Serine/threonine-protein kinase D2 ;
nPKC-D2
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背景:
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by diacylglycerol and phorbol esters.,Function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific protein kinase.,PTM:Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,tissue specificity:Widely expressed.,
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细胞定位:
Cytoplasm . Cell membrane . Nucleus . Golgi apparatus, trans-Golgi network . Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. .
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组织表达:
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研究领域:
>>Rap1 signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
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信号通路
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货号: YM9527
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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