Integrin αE (PT1577R) PT™ Rabbit mAb
-YM9419
主要信息
Target
Integrin αE
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
130kD (Calculated)
150kD (Observed)
Conjugate/Modification
Unmodified
货号: YM9419
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
130kD
实测条带
150kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT1577R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
ITGAE
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蛋白名称:
Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]
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别名:
Integrin alpha-E ;
HML-1 antigen ;
Integrin alpha-IEL ;
Mucosal lymphocyte 1 antigen ;
CD antigen CD103 ;
[Cleaved into: Integrin alpha-E light chain ;
Integrin alpha-E heavy chain]
HML-1 antigen ;
Integrin alpha-IEL ;
Mucosal lymphocyte 1 antigen ;
CD antigen CD103 ;
[Cleaved into: Integrin alpha-E light chain ;
Integrin alpha-E heavy chain]
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背景:
integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],
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功能:
Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.,induction:Integrin alpha-E/beta-7 is induced by TGFB1.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 5 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.,tissue specificity:Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.,
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细胞定位:
Membrane; Single-pass type I membrane protein.
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研究领域:
>>Regulation of actin cytoskeleton
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文献引用（{{totalcount}}）
货号: YM9419
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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