Endogenous

IL2

Interleukin-2

IL2 ;
Interleukin-2 ;
IL-2 ;
T-cell growth factor ;
TCGF ;
Aldesleukin

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],

Disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,Function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family.,

Secreted.

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>PI3K-Akt signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Intestinal immune network for IgA production ;
>>Type I diabetes mellitus ;
>>Yersinia infection ;
>>Chagas disease ;
>>Measles ;
>>Human T-cell leukemia virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Autoimmune thyroid disease ;
>>Inflammatory bowel disease ;
>>Allograft rejection ;
>>Graft-versus-host disease