SLFN12 (PT0798R) PT™ Rabbit mAb
-YM8893
主要信息
Target
SLFN12
Host Species
Rabbit
Reactivity
Human
Applications
WB, FC
MW
64kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8893
规格
价格
货期
数量
200μL
￥3,580.00
一周
0
100μL
￥1,960.00
一周
0
40μL
￥960.00
一周
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:1000-5000; FC 1:100-300
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
实测条带
64kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0798R
同种型
IgG,Kappa
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
特异性:
Endogenous
展开内容
基因名称:
SLFN12
展开内容
蛋白名称:
Ribonuclease SLFN12;Schlafen family member 12;
展开内容
别名:
SLFN12 ;
Ribonuclease SLFN12 ;
Schlafen family member 12 ;
Ribonuclease SLFN12 ;
Schlafen family member 12 ;
展开内容
背景:
Enables RNA nuclease activity and ribosome binding activity. Involved in apoptotic signaling pathway and rRNA catabolic process. Part of cytosol and nucleus. [provided by Alliance of Genome Resources, Feb 2025]
展开内容
功能:
Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34272366, PubMed:34707099, PubMed:35104454). May play a role in cell differentiation (PubMed:30045019). {ECO:0000269|PubMed:30045019, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34272366, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:35104454}.
展开内容
细胞定位:
Nucleus. Cytoplasm, cytosol.
展开内容
文献引用（{{totalcount}}）
货号: YM8893
规格
价格
货期
数量
200μL
￥3,580.00
一周
0
100μL
￥1,960.00
一周
0
40μL
￥960.00
一周
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}