Endogenous

NGFR

Tumor necrosis factor receptor superfamily member 16

NGFR ;
TNFRSF16 ;
Tumor necrosis factor receptor superfamily member 16 ;
Gp80-LNGFR ;
Low affinity neurotrophin receptor p75NTR ;
Low-affinity nerve growth factor receptor ;
NGF receptor ;
p75 ICD ;
CD antigen CD271

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008],

Domain:Death domain is responsible for interaction with RANBP9.,Domain:The extracellular domain is responsible for interaction with NTRK1.,Function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.,

Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine .

Brain,

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>PI3K-Akt signaling pathway ;
>>Apoptosis - multiple species ;
>>Neurotrophin signaling pathway ;
>>Transcriptional misregulation in cancer