Rab11 (PT0823R) PT™ Rabbit mAb
-YM8582
主要信息
Target
RB11A,Rab11B
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
24kD (Calculated)
24kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8582
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:1000-1:5000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
24kD
实测条带
24kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0823R
同种型
IgG, Kappa
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
Endogenous
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基因名称:
RAB11A,RAB11B
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蛋白名称:
Ras-related protein Rab-11A,Rab-11,YL8,Ras-related protein Rab-11B
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别名:
RAB11A ;
Ras-related protein Rab-11A ;
RAB11B ;
YPT3 ;
Ras-related protein Rab-11B ;
GTP-binding protein YPT3 ;
Ras-related protein Rab-11A ;
RAB11B ;
YPT3 ;
Ras-related protein Rab-11B ;
GTP-binding protein YPT3 ;
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数据库链接:
背景:
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways , and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , May 2011]
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功能:
Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP , RAB8A , the exocyst complex , PARD3 , PRKCI , ANXA2 , CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS) , apical surface formation and lumenogenesis (By similarity) . Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
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细胞定位:
Cell membrane ; Lipid-anchor . Recycling endosome membrane ; Lipid-anchor . Cleavage furrow . Cytoplasmic vesicle , phagosome . Cytoplasmic vesicle membrane . Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279) . Localizes to the cleavage furrow (PubMed:15601896) . Colocalizes with PARD3 , PRKCI , EXOC5 , OCLN , PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297) . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211) . Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle , secretory vesicle , synaptic vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle , phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Recruited to phagosomes containing S.aureus.
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研究领域:
>>Endocytosis ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Vasopressin-regulated water reabsorption ;
>>Pancreatic secretion ;
>>Influenza A
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Vasopressin-regulated water reabsorption ;
>>Pancreatic secretion ;
>>Influenza A
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文献引用（{{totalcount}}）
货号: YM8582
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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