Endogenous

RPS6KA3 ISPK1 MAPKAPK1B RSK2

RSK2

Ribosomal protein S6 kinase alpha-3 ;
S6K-alpha-3 ;
90 kDa ribosomal protein S6 kinase 3 ;
p90-RSK 3 ;
p90RSK3 ;
Insulin-stimulated protein kinase 1 ;
ISPK-1 ;
MAP kinase-activated protein kinase 1b ;
MAPK-activated protein kinase 1b ;
MAPKAP kinase 1b ;
MAPKAPK-1b ;
Ribosomal S6 kinase 2 ;
RSK-2 ;
pp90RSK2 ;

ribosomal protein S6 kinase A3(RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Disease:Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-386, as part of the activation process.,PTM:Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4.,tissue specificity:Expressed in many tissues, highest levels in skeletal muscle.,

Nucleus . Cytoplasm .

>>MAPK signaling pathway ;
>>Oocyte meiosis ;
>>mTOR signaling pathway ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Insulin resistance ;
>>Yersinia infection ;
>>Chemical carcinogenesis - receptor activation