CD19 (PT0089R) PT® Rabbit mAb (AbFluor 488)
-YM2222
主要信息
Target
CD19
Host Species
Rabbit
Reactivity
Human,
Applications
WB, IHC, IF, IP, ELISA
MW
110kD (Calculated)
110kD (Observed)
Conjugate/Modification
AbFluor 488
Unmodified
详细信息
推荐稀释比
IF 1:100-500
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
110kD
实测条带
110kD
修饰
Unmodified
偶联
AbFluor 488
克隆性
Monoclonal
克隆号
PT0089R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
CD19
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蛋白名称:
B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
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背景:
CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],
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功能:
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .
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细胞定位:
Membranous
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组织表达:
Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).
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