Ki-67 (PT0321R) PT™ Rabbit mAb (AbFluor 488)
-YM2221
主要信息
Target
Ki-67
Host Species
Rabbit
Reactivity
Human, Mouse, Rat,
Applications
IF,
MW
359kD (Calculated)
359kD (Observed)
Conjugate/Modification
AbFluor 488
Unmodified
详细信息
推荐稀释比
IF 1:100-500
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
359kD
实测条带
359kD
修饰
Unmodified
偶联
AbFluor 488
克隆性
Monoclonal
克隆号
PT0321R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
MKI67
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蛋白名称:
Ki 67
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别名:
MKI67 ;
Antigen KI-67
Antigen KI-67
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背景:
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009],
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功能:
developmental stage:Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected.,Function:Thought to be required for maintaining cell proliferation.,online information:Ki-67 entry,similarity:Contains 1 FHA domain.,subcellular location:Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.,subunit:Interacts with KIF15. Binds through the FHA domain to MKI67IP.,
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细胞定位:
Nucleus
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组织表达:
Nuclear
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