The antiserum was produced against synthesized peptide derived from human Caspase-1. AA range:161-210

Cleaved-Caspase-1 (D210) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.

CASP1 IL1BC IL1BCE

Caspase-1

CASP1 ;
IL1BC ;
IL1BCE ;
Caspase-1 ;
CASP-1 ;
Interleukin-1 beta convertase ;
IL-1BC ;
Interleukin-1 beta-converting enzyme ;
ICE ;
IL-1 beta-converting enzyme ;
p45 ;
[Cleaved into: Caspase-1 subunit p20 ;
Caspase-1 subunit p10]

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits , large and small , that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1 , a cytokine involved in the processes such as inflammation , septic shock , and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq , Mar 2012] ,

Alternative products:Additional isoforms seem to exist ,Catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-. ,enzyme regulation:Specifically inhibited by the cowpox virus Crma protein. ,Function:Thiol protease that cleaves IL-1 beta between an Asp and an Ala , releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Can also promote apoptosis. ,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism. ,similarity:Belongs to the peptidase C14A family. ,similarity:Contains 1 CARD domain. ,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers , each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome , a protein complex which also includes PYCARD , CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. ,tissue specificity:Expressed in larger amounts in spleen and lung. Detected in liver , heart , small intestine , colon , thymus , prostate , skeletal muscle , peripheral blood leukocytes , kidney and testis. No expression in the brain. ,

Cytoplasm . Cell membrane .

>>Necroptosis ;
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>C-type lectin receptor signaling pathway ;
>>Amyotrophic lateral sclerosis ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Yersinia infection ;
>>Influenza A ;
>>Coronavirus disease - COVID-19 ;
>>Lipid and atherosclerosis