Purified recombinant Human IL-1B

This recombinant monoclonal antibody can detects endogenous levels of IL-1B protein.

IL1B IL1F2

Interleukin-1 beta (IL-1 beta) (Catabolin)

IL-1 ;
IL1F2 ;
IL1beta ;
IL1-BETA ;
Catabolin antibody ;
H1 antibody ;
IFN beta inducing factor antibody ;
IL 1 antibody ;
IL 1 beta antibody ;
IL-1 beta antibody ;
IL1 antibody ;
IL1 BETA antibody ;
IL1B antibody ;
IL1B_HUMAN antibody ;
IL1F2 antibody ;
Interleukin 1 beta antibody ;
Interleukin 1 beta precursor antibody ;
interleukin 1 ;
beta antibody ;
Interleukin-1 beta antibody ;
OAF antibody ;
Osteoclast activating factor antibody ;
OTTHUMP00000162031 antibody ;
Preinterleukin 1 beta antibody ;
Preinterleukin beta antibody ;
Pro interleukin 1 beta antibody ;
IL-1β ;
IL-1B nanobody ;

IL-1β in humans and mice does not encode a typical signal peptide and , as a result , newly synthesized pro-IL-1β accumulates within the cytoplasm of activated monocytes and macrophages . Conversion of the inactive pro-IL-1β to its mature form requires the proteolytic action of IL-1β-converting enzyme (ICE) , also termed caspase-1 . Secretion of mature IL-1β from LPS-activated monocytes/macrophages is not a constitutive process. These cells must encounter a secondary stimulus that specifically activates the posttranslational processing events . Moreover , owing to its pro-inflammatory nature , IL-1β is regarded as a tumor-promoting cytokine. In fact , enhanced tumor metastasis and angiogenesis has been observed under the influence of IL-1β . IL-1β is able to facilitate tumor progression in murine models of lung cancer. In addition , upregulation of metastasis and tumor angiogenesis by IL-1β has been associated with increased activity of matrix metalloproteinases and expression of the pro-angiogenic molecule hepatocyte growth factor .

Interleukin (IL) -1β is a cytokine with a key role in the pathophysiology of local and systemic inflammation. IL-1β induces cytokine , chemokine , proinflammatory molecule secretion , and adhesion molecule expression in diverse cells.

Cytoplasm , cytosol . Secreted . Lysosome . Secreted , extracellular exosome . The precursor is cytosolic (PubMed:15192144) . In response to inflammasome-activating signals , such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome , cleaved and secreted (PubMed:24201029 , PubMed:33377178 , PubMed:33883744) . Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744) . In contrast , the precursor form is not released , due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744) . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059) . .