Purified recombinant Human CD10

This recombinant monoclonal antibody can detects endogenous levels of CD10 protein.

MME EPN

Neprilysin

MME ;
EPN ;
Neprilysin ;
Atriopeptidase ;
Common acute lymphocytic leukemia antigen ;
CALLA ;
Enkephalinase ;
Neutral endopeptidase 24.11 ;
NEP ;
Neutral endopeptidase ;
Skin fibroblast elastase ;
SFE ;
CD antigen CD10

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) .This protein is present on leukemic cells of pre-B phenotype , which represent 85% of cases of ALL.This protein is not restricted to leukemic cells , however , and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney , where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon , enkephalins , substance P , neurotensin , oxytocin , and bradykinin.This gene , which encodes a 100-kD type II transmembrane glycoprotein , exists in a single copy of greater than 45 kb. The 5' untranslated region ofThis

Catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues , particularly with Phe or Tyr at P1'. ,cofactor:Binds 1 zinc ion per subunit. ,Disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia. ,enzyme regulation:Inhibited in a dose dependent manner by opiorphin. ,Thermolysin-like specificity , but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF) . ,similarity:Belongs to the peptidase M13 family. ,

Cell membrane; Single-pass type II membrane protein.