Cleaved Spectrin α II (Asp1185) Cell-Based Colorimetric ELISA Kit
-KA3932C
主要信息
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Unmodified
检测方法
Colorimetric
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Cleaved Spectrin α II (Asp1185) Rabbit pAb
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抗原&靶点信息
基因名称:
SPTAN1
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蛋白名称:
Spectrin alpha chain non-erythrocytic 1
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别名:
SPTAN1 ;
NEAS ;
SPTA2 ;
Spectrin alpha chain ;
non-erythrocytic 1 ;
Alpha-II spectrin ;
Fodrin alpha chain ;
Spectrin,non-erythroid alpha subunit
NEAS ;
SPTA2 ;
Spectrin alpha chain ;
non-erythrocytic 1 ;
Alpha-II spectrin ;
Fodrin alpha chain ;
Spectrin,non-erythroid alpha subunit
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背景:
function:Fodrin , which seems to be involved in secretion , interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. ,PTM:Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. ,similarity:Belongs to the spectrin family. ,similarity:Contains 1 SH3 domain. ,similarity:Contains 23 spectrin repeats. ,similarity:Contains 3 EF-hand domains. ,subunit:Like erythrocyte spectrin , the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM. ,
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功能:
regulation of actin polymerization or depolymerization , negative regulation of organelle organization , regulation of actin filament length , regulation of actin filament polymerization , regulation of actin filament depolymerization ,negative regulation of actin filament depolymerization , negative regulation of actin filament polymerization , negative regulation of protein complex assembly , regulation of protein polymerization , negative regulation of protein polymerization , regulation of cellular component size , regulation of actin cytoskeleton organization , regulation of actin filament-based process , regulation of organelle organization , negative regulation of protein complex disassembly ,regulation of protein complex disassembly , regulation of protein complex assembly , regulation of cellular component biogenesis , negative regulation of cellular component organization , regulation of cytoskeleton organization , negative regulation of cytoskeleton organization , actin filament capping ,
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细胞定位:
Cytoplasm , cytoskeleton. Cytoplasm , cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. .
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