GAPDH (PT0004R) Rabbit mAb
-YM8016
主要信息
Target
GAPDH
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Rabbit, Dog, Monkey
Applications
WB, ELISA
MW
37kD (Calculated)
37kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8016
规格
价格
货期
数量
1mL
￥6,800.00
现货
0
500μL
￥4,000.00
现货
0
100μL
￥920.00
现货
0
加入购物车
已收藏
收藏
偶联抗体
GAPDH (2B8) Mouse mAb (AbFluor 350)
GAPDH (2B8) Mouse mAb (AbFluor 405)
GAPDH (2B8) Mouse mAb (AbFluor 488)
GAPDH (2B8) Mouse mAb (AbFluor 555)
GAPDH (2B8) Mouse mAb (AbFluor 594)
GAPDH (2B8) Mouse mAb (AbFluor 647)
GAPDH (2B8) Mouse mAb (AbFluor 680)
GAPDH (2B8) Mouse mAb (Biotin)
GAPDH (2B8) Mouse mAb (Cy3)
GAPDH (2B8) Mouse mAb (Cy5)
GAPDH (2B8) Mouse mAb (FITC)
GAPDH (2B8) Mouse mAb (HRP)
详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
37kD
实测条带
37kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0004R
同种型
IgG, Kappa
相关产品
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RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human protein. AA range:200-300
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
Endogenous
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基因名称:
GAPDH
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蛋白名称:
Glyceraldehyde-3-phosphate dehydrogenase
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别名:
GAPDH ;
GAPD ;
CDABP0047 ;
OK/SW-cl.12 ;
Glyceraldehyde-3-phosphate dehydrogenase ;
GAPDH ;
Peptidyl-cysteine S-nitrosylase GAPDH
GAPD ;
CDABP0047 ;
OK/SW-cl.12 ;
Glyceraldehyde-3-phosphate dehydrogenase ;
GAPDH ;
Peptidyl-cysteine S-nitrosylase GAPDH
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背景:
glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Homo sapiens This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism , the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD) . The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also , this protein contains a peptide that has antimicrobial activity against E. coli , P. aeruginosa , and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins , the regulation of mRNA stability , and acting as a transferri
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功能:
Catalytic activity:D-glyceraldehyde 3-phosphate + phosphate + NAD (+) = 3-phospho-D-glyceroyl phosphate + NADH. ,Function:Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway. ,online information:Glyceraldehyde 3-phosphate dehydrogenase entry ,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1. ,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. ,PTM:Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation , which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis. ,sequence Caution:Differs quite extensively. ,similarity:Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. ,subcellular location:Postnuclear and Perinuclear regions. ,subunit:Homotetramer. ,subunit:Homotetramer. Binds PRKCI. ,
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细胞定位:
Cytoplasm , cytosol . Nucleus . Cytoplasm , perinuclear region . Membrane . Cytoplasm , cytoskeleton . Translocates to the nucleus following S-nitrosylation and interaction with SIAH1 , which contains a nuclear localization signal (By similarity) . Postnuclear and Perinuclear regions (PubMed:12829261) . .
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研究领域:
>>Glycolysis / Gluconeogenesis ;
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of amino acids ;
>>HIF-1 signaling pathway ;
>>Alzheimer disease ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Diabetic cardiomyopathy
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of amino acids ;
>>HIF-1 signaling pathway ;
>>Alzheimer disease ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Diabetic cardiomyopathy
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信号通路
文献引用（{{totalcount}}）
货号: YM8016
规格
价格
货期
数量
1mL
￥6,800.00
现货
0
500μL
￥4,000.00
现货
0
100μL
￥920.00
现货
0
加入购物车
已收藏
收藏
偶联抗体
GAPDH (2B8) Mouse mAb (AbFluor 350)
GAPDH (2B8) Mouse mAb (AbFluor 405)
GAPDH (2B8) Mouse mAb (AbFluor 488)
GAPDH (2B8) Mouse mAb (AbFluor 555)
GAPDH (2B8) Mouse mAb (AbFluor 594)
GAPDH (2B8) Mouse mAb (AbFluor 647)
GAPDH (2B8) Mouse mAb (AbFluor 680)
GAPDH (2B8) Mouse mAb (Biotin)
GAPDH (2B8) Mouse mAb (Cy3)
GAPDH (2B8) Mouse mAb (Cy5)
GAPDH (2B8) Mouse mAb (FITC)
GAPDH (2B8) Mouse mAb (HRP)
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