Synthesized peptide derived from human CD86. AA range:115-185

This antibody detects endogenous levels of Human CD86

CD86 CD28LG2

CD86

T-lymphocyte activation antigen CD86 ;
Activation B7-2 antigen ;
B70 ;
BU63 ;
CTLA-4 counter-receptor B7.2 ;
FUN-1 ;
CD antigen CD86 ;

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells , and it is the ligand for two proteins at the cell surface of T cells , CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq , May 2011] ,

Function:Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production , by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells , such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters , and thus acts as a negative regulator of T-cell activation. ,online information:CD86 entry ,PTM:Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. ,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subunit:Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable) . Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. ,tissue specificity:Expressed by activated B-lymphocytes and monocytes. ,

Cell membrane; Single-pass type I membrane protein.

>>Cell adhesion molecules ;
>>Toll-like receptor signaling pathway ;
>>Intestinal immune network for IgA production ;
>>Type I diabetes mellitus ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Transcriptional misregulation in cancer ;
>>Autoimmune thyroid disease ;
>>Systemic lupus erythematosus ;
>>Rheumatoid arthritis ;
>>Allograft rejection ;
>>Graft-versus-host disease ;
>>Viral myocarditis