This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010],
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功能:
similarity:Belongs to the GRXCR1 family.,similarity:Contains 1 glutaredoxin domain.,
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细胞定位:
Cell projection, stereocilium . Cell projection, microvillus . Cell projection, kinocilium . In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. .
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组织表达:
Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.