Synthetic peptide from human protein at AA range: 1-50

The antibody detects endogenous IL-8RA

CXCR1 CMKAR1 IL8RA

C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)

C-X-C chemokine receptor type 1 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;

C-X-C motif chemokine receptor 1(CXCR1) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008],

Function:Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,

Cell membrane; Multi-pass membrane protein.

Blood,Placenta,

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection