Synthetic peptide from human protein at AA range: 100-170

The antibody detects endogenous E2F-1 protein

E2F1 RBBP3

E2F transcription factor 1

E2F1 RBBP3

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain , a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP) , a transactivation domain enriched in acidic amino acids , and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members , E2F2 and E2F3 , have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media

Function:Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site , 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein , in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis. ,PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. ,similarity:Belongs to the E2F/DP family. ,subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle , RB1 becomes phosphorylated in mid-to-late G1 phase , detaches from the DRTF1/E2F complex , rendering E2F transcriptionally active. Viral oncoproteins , notably E1A , T-antigen and HPV E7 , are capable of sequestering RB protein , thus releasing the active complex. Interacts with TRRAP , which probably mediates its interaction with histone acetyltransferase complexes , leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. ,

Nucleus .

>>Endocrine resistance ;
>>Cell cycle ;
>>Mitophagy - animal ;
>>Cellular senescence ;
>>Cushing syndrome ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>MicroRNAs in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Pancreatic cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Bladder cancer ;
>>Chronic myeloid leukemia ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer