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Ebi3 Rabbit pAb

-YT5645

2 5
主要信息
Target

Ebi3

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

WB, ELISA

MW

25kD (Observed)

Conjugate/Modification

Unmodified

货号: YT5645
规格
价格
货期
数量
200μL
¥3,780.00
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0

100μL
¥2,300.00
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40μL
¥960.00
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Ebi3 Polyclonal Antibody detects endogenous levels of Ebi3 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
25kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from the Internal region of human EBI3. AA range:101-150
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特异性:
Ebi3 Polyclonal Antibody detects endogenous levels of Ebi3 protein.
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基因名称:
EBI3
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蛋白名称:
Interleukin-27 subunit beta
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别名:
EBI3 ;
IL27B ;
Interleukin-27 subunit beta ;
IL-27 subunit beta ;
IL-27B ;
Epstein-Barr virus-induced gene 3 protein ;
EBV-induced gene 3 protein
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数据库链接:
Organism 基因 ID SwissProt
Human 10148; Q14213;
Mouse 50498; O35228;
背景:
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008],
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功能:
Function:Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.,induction:By EBV.,online information:Interleukin-27 entry,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer with IL27. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1.,
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细胞定位:
Secreted .
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组织表达:
B-cell,Pancreas,
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研究领域:
>>Cytokine-cytokine receptor interaction ;
>>Th17 cell differentiation
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货号: YT5645
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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