The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110

OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein.

OAS2

2'-5'-oligoadenylate synthase 2

OAS2 ;
2'-5'-oligoadenylate synthase 2 ;
2-5' ;
oligo ;
A ;
synthase 2 ;
2-5A synthase 2 ;
p69 OAS / p71 OAS ;
p69OAS / p71OAS

2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

Catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,Function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer.,

Cytoplasm . Cytoplasm, perinuclear region .

Blood,Colon,Testis,Uterus,

>>NOD-like receptor signaling pathway ;
>>Hepatitis C ;
>>Measles ;
>>Influenza A ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19