The antiserum was produced against synthesized peptide derived from the C-terminal region of human PPIB. AA range:151-200

CyPB Polyclonal Antibody detects endogenous levels of CyPB protein.

PPIB

Peptidyl-prolyl cis-trans isomerase B

PPIB ;
CYPB ;
Peptidyl-prolyl cis-trans isomerase B ;
PPIase B ;
CYP-S1 ;
Cyclophilin B ;
Rotamase B ;
S-cyclophilin ;
SCYLP

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],

Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,Caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,

Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

Brain,Fetal brain cortex,Prostate,Skin,