The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALPP/ALPPL2. AA range:1-50

ALPP/ALPPL2 Polyclonal Antibody detects endogenous levels of ALPP/ALPPL2 protein.

ALPP/ALPPL2

Alkaline phosphatase, placental type/Alkaline phosphatase, placental-like

ALPP ;
PLAP ;
Alkaline phosphatase, placental type ;
Alkaline phosphatase Regan isozyme ;
Placental alkaline phosphatase 1 ;
PLAP-1 ;
ALPPL2 ;
ALPPL ;
Alkaline phosphatase, placental-likeALP-1 ;
Alkaline phosphatase Nagao isozyme ;
Germ cell alkaline phosphatase ;
GCAP ;
Placental alkaline phosphatase-like ;
PLAP-like

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],

Catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,

Cell membrane; Lipid-anchor, GPI-anchor .

Detected in placenta (at protein level).

>>Thiamine metabolism ;
>>Folate biosynthesis ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors