TPH1 Rabbit pAb
-YT4710
主要信息
Target
Tryptophan Hydroxylase
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
51kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4710
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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已收藏
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
TPH1 Polyclonal Antibody detects endogenous levels of TPH1 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
51kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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ELISA Kits
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Tryptophan Hydroxylase. AA range:231-280
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特异性:
TPH1 Polyclonal Antibody detects endogenous levels of TPH1 protein.
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基因名称:
TPH1
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蛋白名称:
Tryptophan 5-hydroxylase 1
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别名:
TPH1 ;
TPH ;
TPRH ;
TRPH ;
Tryptophan 5-hydroxylase 1 ;
Tryptophan 5-monooxygenase 1
TPH ;
TPRH ;
TRPH ;
Tryptophan 5-hydroxylase 1 ;
Tryptophan 5-monooxygenase 1
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背景:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009],
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功能:
Catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,subunit:Multimer of identical subunits.,tissue specificity:Isoform 2 seems to be less widely expressed than isoform 1.,
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细胞定位:
cytosol,neuron projection,
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组织表达:
[Isoform 2]: Seems to be less widely expressed than isoform 1.
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研究领域:
>>Tryptophan metabolism ;
>>Folate biosynthesis ;
>>Metabolic pathways ;
>>Serotonergic synapse
>>Folate biosynthesis ;
>>Metabolic pathways ;
>>Serotonergic synapse
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文献引用（{{totalcount}}）
货号: YT4710
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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