The antiserum was produced against synthesized peptide derived from human TAF15. AA range:351-400

TAF II p68 Polyclonal Antibody detects endogenous levels of TAF II p68 protein.

TAF15

TATA-binding protein-associated factor 2N

TAF15 ;
RBP56 ;
TAF2N ;
TATA-binding protein-associated factor 2N ;
68 kDa TATA-binding protein-associated factor ;
TAF ;
II ;
68 ;
TAFII68 ;
RNA-binding protein 56

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],

Disease:A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.,Function:RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).,PTM:Arg-206 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RRM TET family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.,tissue specificity:Ubiquitous. Observed in all fetal and adult tissues.,

Nucleus . Cytoplasm . Shuttles from the nucleus to the cytoplasm.

Ubiquitous. Observed in all fetal and adult tissues.

>>Basal transcription factors ;
>>Transcriptional misregulation in cancer