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SRPK1 Rabbit pAb

-YT4422

2 5
主要信息
Target

SRPK1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, ELISA

MW

95kD (Observed)

Conjugate/Modification

Unmodified

货号: YT4422
规格
价格
货期
数量
200μL
¥3,780.00
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0

100μL
¥2,300.00
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40μL
¥960.00
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
SRPK1 Polyclonal Antibody detects endogenous levels of SRPK1 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
95kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human SRPK1. AA range:521-570
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特异性:
SRPK1 Polyclonal Antibody detects endogenous levels of SRPK1 protein.
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基因名称:
SRPK1
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蛋白名称:
SRSF protein kinase 1
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别名:
SRPK1 ;
SRSF protein kinase 1 ;
SFRS protein kinase 1 ;
Serine/arginine-rich protein-specific kinase 1 ;
SR-protein-specific kinase 1
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数据库链接:
Organism 基因 ID SwissProt
Human 6732; Q96SB4;
Mouse 20815; O70551;
背景:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Ser-51 and Ser-555.,Function:Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Present in a seven component complex, the toposome, which separates entangled circular chromatin DNA during chromosome segregation. The extended N-terminal domain of isoform 1 binds to the nuclear scaffold-associated protein SAFB suggesting this isoform may phosphorylate splicing factors in close vicinity to the nuclear matrix.,tissue specificity:Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2.,
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细胞定位:
[Isoform 2]: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.; [Isoform 1]: Cytoplasm. Nucleus matrix. Microsome. Mainly localized in the microsomal fraction and the cytoplasm, and to a lesser extent in the nuclear matrix.; Cytoplasm . Nucleus, nucleoplasm . Nucleus speckle . Chromosome . Preferentially localizes to the promoter of gene coding regions. .
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组织表达:
Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1.
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研究领域:
>>Herpes simplex virus 1 infection
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货号: YT4422
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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