RECK Rabbit pAb
-YT4036
主要信息
Target
RECK
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, WB, ELISA
MW
110kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4036
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
RECK Polyclonal Antibody detects endogenous levels of RECK protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
110kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human RECK. AA range:21-70
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特异性:
RECK Polyclonal Antibody detects endogenous levels of RECK protein.
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基因名称:
RECK
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蛋白名称:
Reversion-inducing cysteine-rich protein with Kazal motifs
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别名:
RECK ;
ST15 ;
Reversion-inducing cysteine-rich protein with Kazal motifs ;
hRECK ;
Suppressor of tumorigenicity 15 protein
ST15 ;
Reversion-inducing cysteine-rich protein with Kazal motifs ;
hRECK ;
Suppressor of tumorigenicity 15 protein
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背景:
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
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功能:
Function:Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.,PTM:N-glycosylated.,similarity:Contains 3 Kazal-like domains.,subunit:Interacts with MMP-9.,tissue specificity:Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.,
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细胞定位:
Cell membrane ; Lipid-anchor, GPI-anchor .
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组织表达:
Expressed in various tissues and untransformed cells (PubMed:9789069). It is undetectable in tumor-derived cell lines and oncogenically transformed cells (PubMed:9789069).
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研究领域:
>>MicroRNAs in cancer
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货号: YT4036
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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