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PIPK I γ Rabbit pAb

-YT3735

2 5
主要信息
Target

PIPK I γ

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

WB, ELISA

MW

80kD (Observed)

Conjugate/Modification

Unmodified

货号: YT3735
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
PIPK I γ Polyclonal Antibody detects endogenous levels of PIPK I γ protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
80kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human PIP5K1C. AA range:305-354
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特异性:
PIPK I γ Polyclonal Antibody detects endogenous levels of PIPK I γ protein.
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基因名称:
PIP5K1C
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蛋白名称:
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
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别名:
PIP5K1C ;
KIAA0589 ;
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma ;
PIP5K1-gamma ;
PtdIns ;
4 ;
P-5-kinase 1 gamma ;
Phosphatidylinositol 4-phosphate 5-kinase type I gamma ;
PIP5KIgamma
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数据库链接:
Organism 基因 ID SwissProt
Human 23396; O60331;
Mouse O70161;
背景:
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma(PIP5K1C) Homo sapiens This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010],
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功能:
Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,Disease:Defects in PIP5K1C are the cause of lethal congenital contractural syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.,enzyme regulation:Activated by interaction with TLN2.,Function:Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.,similarity:Contains 1 PI5K domain.,subcellular location:Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.,subunit:Interacts with TLN1 and CSK (By similarity). Interacts with TLN2 and ARF6.,
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细胞定位:
Cell membrane; Peripheral membrane protein; Cytoplasmic side . Endomembrane system . Cytoplasm . Cell junction, focal adhesion . Cell junction, adherens junction . Cell projection, ruffle membrane . Cell projection, phagocytic cup . Cell projection, uropodium . Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.; [Isoform 2]: Cytoplasm. Nucleus.
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组织表达:
[Isoform 1]: Isoform 1 is strongly expressed in brain and also detected in heart and lung. ; [Isoform 2]: Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney. ; [Isoform 3]: Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney.
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研究领域:
>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Focal adhesion ;
>>Fc gamma R-mediated phagocytosis ;
>>Regulation of actin cytoskeleton ;
>>Yersinia infection ;
>>Choline metabolism in cancer
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货号: YT3735
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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