Osteopontin Rabbit pAb
-YT3467
主要信息
Target
OPN
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
货号: YT3467
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:100-500; IF/ICC1:100-500; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
OPN Polyclonal Antibody detects endogenous levels of OPN protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
RRID号
AB_3665642
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Osteopontin. AA range:261-310
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特异性:
OPN Polyclonal Antibody detects endogenous levels of OPN protein.
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基因名称:
SPP1
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蛋白名称:
Osteopontin
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别名:
SPP1 ;
BNSP ;
OPN ;
PSEC0156 ;
Osteopontin ;
Bone sialoprotein 1 ;
Nephropontin ;
Secreted phosphoprotein 1 ;
SPP-1 ;
Urinary stone protein ;
Uropontin
BNSP ;
OPN ;
PSEC0156 ;
Osteopontin ;
Bone sialoprotein 1 ;
Nephropontin ;
Secreted phosphoprotein 1 ;
SPP-1 ;
Urinary stone protein ;
Uropontin
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背景:
secreted phosphoprotein 1 (SPP1) Homo sapiens The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Oct 2011] ,
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功能:
Disease:This protein plays a principal role in urinary stone formation as the stone matrix. ,Function:Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. ,Function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. ,online information:Osteopontin entry ,PTM:Extensively phosphorylated on clustered serine residues. ,PTM:N- and O-glycosylated. ,similarity:Belongs to the osteopontin family. ,subunit:Ligand for integrin alpha-V/beta-3. ,
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细胞定位:
Secreted.
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组织表达:
研究领域:
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Toll-like receptor signaling pathway ;
>>GnRH secretion ;
>>Human papillomavirus infection
>>Apelin signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Toll-like receptor signaling pathway ;
>>GnRH secretion ;
>>Human papillomavirus infection
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信号通路
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction
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货号: YT3467
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
加入购物车
已收藏
收藏
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