Na+ CP type VIIα Rabbit pAb
-YT2968
主要信息
Target
Na+ CP type VIIα
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, IF
MW
200kD (Observed)
Conjugate/Modification
Unmodified
货号: YT2968
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000;
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Na+ CP type VIIα Polyclonal Antibody detects endogenous levels of Na+ CP type VIIα protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
200kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human SCN7A. AA range:771-820
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特异性:
Na+ CP type VIIα Polyclonal Antibody detects endogenous levels of Na+ CP type VIIα protein.
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基因名称:
SCN7A
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蛋白名称:
Sodium channel protein type 7 subunit alpha
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别名:
SCN7A ;
SCN6A ;
Sodium channel protein type 7 subunit alpha ;
Putative voltage-gated sodium channel subunit alpha Nax ;
Sodium channel protein cardiac and skeletal muscle subunit alpha ;
Sodium channel protein type VII subunit alpha
SCN6A ;
Sodium channel protein type 7 subunit alpha ;
Putative voltage-gated sodium channel subunit alpha Nax ;
Sodium channel protein cardiac and skeletal muscle subunit alpha ;
Sodium channel protein type VII subunit alpha
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背景:
This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011],
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功能:
Domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,Function:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the sodium channel family.,tissue specificity:Heart and uterus.,
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细胞定位:
Cell membrane ; Multi-pass membrane protein .
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组织表达:
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研究领域:
>>Adrenergic signaling in cardiomyocytes
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文献引用（{{totalcount}}）
货号: YT2968
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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