The antiserum was produced against synthesized peptide derived from human IKZF3. AA range:361-410

Ikaros 3 Polyclonal Antibody detects endogenous levels of Ikaros 3 protein.

IKZF3

Zinc finger protein Aiolos

IKZF3 ;
ZNFN1A3 ;
Zinc finger protein Aiolos ;
Ikaros family zinc finger protein 3

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012],

Function:Transcription factor that plays an important role in the regulation of lymphocyte differentiation.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.,

Nucleus . Cytoplasm .; [Isoform 1]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 11]: Nucleus .; [Isoform 14]: Nucleus . Cytoplasm .; [Isoform 12]: Cytoplasm .

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.