The antiserum was produced against synthesized peptide derived from human MYST2. AA range:131-180

HBO1 Polyclonal Antibody detects endogenous levels of HBO1 protein.

KAT7

Histone acetyltransferase KAT7

KAT7 ;
HBO1 ;
HBOa ;
MYST2 ;
Histone acetyltransferase KAT7 ;
Histone acetyltransferase binding to ORC1 ;
Lysine acetyltransferase 7 ;
MOZ ;
YBF2/SAS3,SAS2 and TIP60 protein 2 ;
MYST-2

catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. ,domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. ,domain:The N-terminus is involved in transcriptional repression , while the C-terminus mediates AR-interaction. ,function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity , a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the MYST (SAS/MOZ) family. ,similarity:Contains 1 C2HC-type zinc finger. ,subunit:Component of the HBO1 complex composed at least of ING4 or ING5 , MYTS2/HBO1 , EAF6 , and one of PHF15 , PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. ,tissue specificity:Ubiquitously expressed , with highest levels in testis. ,

Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. ,Domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. ,Domain:The N-terminus is involved in transcriptional repression , while the C-terminus mediates AR-interaction. ,Function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity , a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the MYST (SAS/MOZ) family. ,similarity:Contains 1 C2HC-type zinc finger. ,subunit:Component of the HBO1 complex composed at least of ING4 or ING5 , MYTS2/HBO1 , EAF6 , and one of PHF15 , PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. ,tissue specificity:Ubiquitously expressed , with highest levels in testis. ,

Nucleus . Chromosome . Chromosome , centromere . Cytoplasm , cytosol . Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067 , PubMed:20129055) . Localizes to transcription start sites (PubMed:21753189 , PubMed:24065767) . Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581) . Localizes to centromeres in G1 phase (PubMed:27270040) . .