The antiserum was produced against synthesized peptide derived from human TCEB3. AA range:131-180

Elongin A1 Polyclonal Antibody detects endogenous levels of Elongin A1 protein.

TCEB3

Transcription elongation factor B polypeptide 3

TCEB3 ;
MSTP059 ;
Transcription elongation factor B polypeptide 3 ;
Elongin 110 kDa subunit ;
Elongin-A ;
EloA ;
RNA polymerase II transcription factor SIII subunit A1 ;
SIII p110

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008],

Domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,Function:SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).,similarity:Contains 1 F-box domain.,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A.,

Nucleus .

Epithelium,Heart,Lung,Umbilical vein,