function:May inhibit cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,
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功能:
Function:May inhibit cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,
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细胞定位:
Mitochondrion matrix. Nucleus. A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
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组织表达:
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.