CLK4 Rabbit pAb
-YT0973
主要信息
Target
CLK4
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
65kD (Observed)
Conjugate/Modification
Unmodified
货号: YT0973
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
CLK4 Polyclonal Antibody detects endogenous levels of CLK4 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
65kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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RS0002
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YM3028
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human CLK4. AA range:101-150
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特异性:
CLK4 Polyclonal Antibody detects endogenous levels of CLK4 protein.
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基因名称:
CLK4
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蛋白名称:
Dual specificity protein kinase CLK4
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别名:
CLK4 ;
Dual specificity protein kinase CLK4 ;
CDC-like kinase 4
Dual specificity protein kinase CLK4 ;
CDC-like kinase 4
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背景:
CDC like kinase 4(CLK4) Homo sapiens The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU.,PTM:Autophosphorylates on all three types of residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with UBL5.,tissue specificity:Expressed in liver, kidney, heart, muscle and brain.,
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细胞定位:
Nucleus .
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组织表达:
Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
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研究领域:
>>Legionellosis
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货号: YT0973
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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