The antiserum was produced against synthesized peptide derived from human CDK2. AA range:231-280

Cdk2 Polyclonal Antibody detects endogenous levels of Cdk2 protein.

CDK2

Cyclin-dependent kinase 2

CDK2 ;
CDKN2 ;
Cyclin-dependent kinase 2 ;
Cell division protein kinase 2 ;
p33 protein kinase

cyclin dependent kinase 2(CDK2) Homo sapiens This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it.,Function:Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1.,

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).

Epithelium,Lung,Placenta,

>>FoxO signaling pathway ;
>>Cell cycle ;
>>Oocyte meiosis ;
>>p53 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Cellular senescence ;
>>Progesterone-mediated oocyte maturation ;
>>Cushing syndrome ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Prostate cancer ;
>>Small cell lung cancer ;
>>Gastric cancer