Synthesized peptide derived from human MKP-3 (Phospho-Ser197)

This antibody detects endogenous levels of MKP-3 (Phospho-Ser197) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DGsPL

DUSP6 MKP3 PYST1

MKP-3 (Phospho-Ser197)

Dual specificity protein phosphatase 6 ;
EC 3.1.3.48 ;
Dual specificity protein phosphatase PYST1 ;
Mitogen-activated protein kinase phosphatase 3 ;
MAP kinase phosphatase 3 ;
MKP-3 ;

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t

Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Inactivates MAP kinases. Has a specificity for the ERK family.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

Cytoplasm .

Expressed in keratinocytes (at protein level).

>>MAPK signaling pathway ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia