YAP (Phospho Ser397) Rabbit pAb
-YP1554
主要信息
Target
YAP
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
67kD (Observed)
Conjugate/Modification
Phospho
货号: YP1554
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
67kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
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YT4924
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ELISA Kits
Total YAP Cell-Based Colorimetric ELISA Kit
KA3612C
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ELISA Kits
YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human YAP (Ser397)
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特异性:
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
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基因名称:
YAP1 YAP65
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蛋白名称:
YAP (Ser397)
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别名:
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65 ;
65 kDa Yes-associated protein ;
YAP65 ;
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背景:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],
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功能:
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
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细胞定位:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
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组织表达:
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
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研究领域:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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信号通路
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货号: YP1554
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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