The antiserum was produced against synthesized peptide derived from human MARCKS around the phosphorylation site of Ser163. AA range:136-185

Phospho-MARCKS (S163) Polyclonal Antibody detects endogenous levels of MARCKS protein only when phosphorylated at S163.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KKsFK

MARCKS

Myristoylated alanine-rich C-kinase substrate

MARCKS ;
MACS ;
PRKCSL ;
Myristoylated alanine-rich C-kinase substrate ;
MARCKS ;
Protein kinase C substrate ;
80 kDa protein, light chain ;
80K-L protein ;
PKCSL

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],

Function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,

Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .

Blood,Brain,Epithelium,Muscle,Skin,

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